高性能インプラント治療・技術を推進する「光機能化インプラントグローバルネット」

チタン生物学的エイジング、光機能化に関する論文紹介

チタン生物学的エイジングならびに光機能化に関する論文紹介を掲載しております。

Peer reviewed publications

Aita H, Hori N, Takeuchi M, Suzuki T, Yamada M, M, Anpo, Ogawa T. The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials, 30:1015-1025, 2009

Att W, Takeuchi M, Suzuki T, Kubo K, Anpo M, Ogawa T. Enhanced osteoblast function on ultraviolet light-treated zirconia. Biomaterials, 30: 12731280, 2009

Hori N, Att W, Ueno T, Sato N, Yamada M, Saruwatari L, Suzuki T, Ogawa T. Age-dependent degradation of protein adsorption capacity of Ti. J Dent Res 88:663-667, 2009

Aita H, Att W, Ueno T, Yamada M, Hori N, Iwasa F, Tsukimura N, Ogawa T. Ultraviolet (UV) light-mediated photofunctionalization of titanium to promote human mesenchymal stem cell migration, attachment, proliferation and differentiation. Acta Biomaterialia, 5: 32473257, 2009   

Suzuki T, Hori N, Att W, Iwasa F, Ueno T, Kubo K, Maeda H. Ogawa T. UV Treatment overcomes Time-Related Degrading Bioactivity of Titanium. Tissue Eng Part A 15: 3679-88, 2009

Att W, Hori N, Iwasa F, Yamada M, Ueno T, Ogawa T. The effect of UV-photofunctionalization on the time-related bioactivity of titanium and chromium-cobalt alloys. Biomaterials, 30: 42684276, 2009

Selected as the Best Image of Year published in Biomaterials in 2009 and honored in the “Annual Biomaterial Poster 2009 in Images”

Hori N, Kimoto K, Kubo K, Suzuki T, Yamada M, Ogawa T. Time-dependent degradation of protein adsorption and cell attachment capacities of titanium. J Jpn Soc Oral Implant 22:97-105, 2009  

Winner of Best Paper Award in Journal of Japanese Society of Oral Impalantology in 2009

Att W, Hori N, Takeuchi M, Ouyang J, Yang Y, Anpo M, Ogawa T. Time-dependent degradation of titanium osteoconductivity: An implication of biological aging of implant materials. Biomaterials. 30: 53525363, 2009

Hori N, Att W, Yamada M, Okada S, Ohno A, Kimoto K, Ogawa T. Ultraviolet light treatment for the restoration of age-related degradation of titanium bioactivity.. Int J Oral Maxillofac Implant, 25:49-62, 2010

Ueno T, Yamada M, Hori N, Suzuki T, Ogawa T. UV photoactivation of titanium enhances osseointegration in a rat model.  Int J Oral Maxillofac Implants, 25:287-294, 2010

Ueno T, Yamada M, Suzuki T, Minamikawa H, Sato N, Hori N, Takeuchi K, Hattori M, Ogawa T. Enhanced bone-titanium integration profile by UV-photofunctionalized titanium in a gap healing model. Biomaterials, 31: 15461557, 2010

Hori N, Ueno T, Minamikawa H, Iwasa F, Yoshino F, Kimoto K, Lee MC, Ogawa T. Electrostatic control of protein adsorption to UV photofunctionalized titanium. Acta Biomaterialia, 6:4175-80, 2010

Iwasa F, Hori N, Ueno T, Minamikawa H, Yamada M, Ogawa T. Enhancement of osteoblast adhesion to UV photofunctionalized titanium via an electrostatic mechanism. Biomaterials, 31: 2717-2727, 2010

Miyauchi T, Yamada M, Yamamoto A, Iwasa F, Suzawa T, Kamijo R, Baba K, Ogawa T. The enhanced characteristics of osteoblast adhesion to photofunctionalized nanoscale TiO2 layers on biomaterials surfaces. Biomaterials, 31: 3827-39, 2010

Suzuki T, Kubo K, Hori N, Yamada M, Kojima N, Maeda H, Ogawa T. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials, 31: 4818-28, 2010

Yamada M, Miyauchi T, Yamamoto A, Iwasa F, Takeuchi M, Anpo M, Sakurai K, Baba K, Ogawa T. Enhancement of adhesion strength and cellular stiffness of osteoblasts on mirror-polished titanium surface by UV-photofunctionalization. Acta Biomaterialia, 12: 4578-88, 2010

Aita H, Hori N, Koshino H, Ogawa T. Application of UV lightinduced biofunctionalization to titanium implant surfaces. Kanagawa Dent College Bulletin, in press

Tsukimura N, Yamada M, Iwasa F, Minamikawa H, Att W, Ueno T, Saruwatari L, Aita H, Chiou WA, Ogawa T. Synergistic effects of UV-photofunctionalization and micro-nano hybrid topography on the biological property of titanium, Biomaterials 32: 4358-4368, 2011

Aita H, Kono M, Toyoshita Y, Ogawa T. Reconsideration of the bioactive potential of titanium. Hokkaido Iryo Daigaku Dental Topics. In press

Iwasa F, Yamada M, Aita H, Sugita Y, Ueno T, Kanuru R, Kubo K, Hasnain H, Att W, Ogawa T. TiO2 micro-nano-hybrid surface to alleviate biological aging of UV-photofunctionalized titanium. Int J Nanomedicine, in press

Hori N, Iwasa F, Tsukimura N, Sugita Y, Ueno T. Effects of UV photofunctionalization on nanotopography-enhanced initial bioactivity of titanium. Acta Biomaterialia, in press

Review and featured articles

Ogawa T. Interview to inventors. “Breakthrough after 45 years: Superosseointegrated implants for dental and orthopedic use” UCLA Invents, 3. 2008

Hori N, Ogawa T. Biological aging of titanium: A historic discovery in science and therapeutics of titanium implants. Quintessence, 28:83-91, 2009

Ogawa T. Paradigm shift in Osseointegration: Advancement from “research” to “science” and a discovery of “biological aging of titanium” offering a new horizon of implant therapy. In Osseointegration Japan Osseointegration Japan Annual Consensus. Dental Implantology. Quintessence Publishing. 2010. 46-59

Ogawa T. Photofunctionalization of TiO2 for optimal integration of titanium with bone. In Benign Photocatalysts --Applications of titanium oxide-based materials. Eds. Prashant Kamat and Masakazu Anpo. Springer US. Chapter 29 (699-713), 2010